At the TU Darmstadt several DFG Collaborative Research Centers and Transregios are coordinated, four of them in Mechanical Engineering.
| Number | Title | Spokesperson |
| 1194 | Interaction between Transport and Wetting Processes | Prof. Dr.-Ing. Peter Stephan, Institute for Technical Thermodynamics |
| 666 | Integral Sheet Metal Design with Higher Order Bifurcations |
Prof. Dr.-Ing. Dipl.-Wirtsch.-Ing. Peter Groche, Institute for Production Engineering and Forming Machines |
| 805 | Control of Uncertainty in Load-Carrying Structures in Mechanical Engineering |
Prof. Dr.-Ing. Peter Pelz, Chair of Fluid Systems |
| TRR 150 | Turbulent, chemically reactive multi-phase flows near walls |
Prof. Dr.-Ing. Johannes Janicka, Working Group Energy and Power Plant Technology; Prof. Dr. Andreas Dreizler, Institute for Reactive Flows and Diagnostics |
